The Stereochemical Course of 4-Hydroxy-2-nonenal Metabolism by Glutathione S-Transferases
نویسندگان
چکیده
منابع مشابه
The stereochemical course of 4-hydroxy-2-nonenal metabolism by glutathione S-transferases.
4-Hydroxy-2-nonenal (HNE) is a toxic aldehyde generated during lipid peroxidation and has been implicated in a variety of pathological states associated with oxidative stress. Glutathione S-transferase (GST) A4-4 is recognized as one of the predominant enzymes responsible for the metabolism of HNE. However, substrate and product stereoselectivity remain to be fully explored. The results from a ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2008
ISSN: 0021-9258
DOI: 10.1074/jbc.m801725200